What Is The Main Cause of Psoriasis ? How to Treat Psoriasis Naturally ?

 

Psoriasis is a chronic, autoimmune-mediated inflammatory disease that is predominantly initiated and perpetuated by T cells. Keratinocyte (KC) proliferation, infiltration of inflammatory cells and angiogenesis are the mainly characteristic histopathology manifestation of psoriasis. The prevalence of psoriasis ranges from 0.1% to 11.4% in different countries; it affects more than 100 million people worldwide , and its incidence is increasing year by year. Psoriasis has a high recurrence rate and is a lifelong disorder that severely reduces the life quality of patients, creating both a physical and psychological burden.

Although the exact pathogenesis of psoriasis remains unclear, it is now widely accepted that gene-gene and environment-gene interactions may affect its onset, manifestation and clinical course . Susceptibility genes for psoriasis have been widely studied by various methods, especially genome-wide association studies (GWAS), to better understand its genetic etiology. Over the past decade, more than 120 susceptibility genes have been associated with psoriasis .

However, most of these GWAS focused on non-coding variants and the contribution to psoriasis of functional variants (including the splicing, frameshift, nonsense, missense variants predicted to be damaging and variants in enhancer or promotor region) in or nearby coding regions are not systematic reviewed. More and more studies and evidence showed that the functional variants play an important role in psoriasis Thereby, whole genome sequencing (WGS) is needed to identify variants related to the genetic etiology of psoriasis. (NEXT: Natural Way to Get Rid Of Psoriasis – Success Stories)